mTOR contributes to ER stress and associated apoptosis in renal tubular cells
نویسندگان
چکیده
Guie Dong,* Yu Liu,* Lei Zhang, Shuang Huang, Han-Fei Ding, and Zheng Dong Department of Cellular Biology and Anatomy, Georgia Reagents University and Charlie Norwood Veterans Affairs (VA) Medical Center, Augusta, Georgia; Department of Nephrology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China; Department of Biochemistry and Molecular Biology, Georgia Reagents University and Charlie Norwood VA Medical Center, Augusta, Georgia; and Cancer Center, Georgia Reagents University and Charlie Norwood VA Medical Center, Augusta, Georgia
منابع مشابه
Re: mTOR Contributes to ER Stress and Associated Apoptosis in Renal Tubular Cells.
ER stress has been implicated in the pathogenesis of both acute and chronic kidney diseases. However, the molecular regulation of ER stress in kidney cells and tissues remains poorly understood. In this study, we examined tunicamycin-induced ER stress in renal proximal tubular cells (RPTC). Tunicamycin induced the phosphorylation and activation of PERK and eIF2α within 2 h in RPTC, which was fo...
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